Engineering Multifunctional Particles for Biological Applications

Grant number: DP170103331 | Funding period: 2017 - 2019

Completed

Abstract

This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biological barriers. This project will develop a platform for the assemble of particles with tailored properties which are expected to provide insights on particle-biological interactions for particle-based therapeutic delivery.

Related publications (26)

Particle engineering enabled by polyphenol-mediated supramolecular networks.

Jiajing Zhou, Zhixing Lin, Matthew Penna, Shuaijun Pan, Yi Ju, Shiyao Li, Yiyuan Han, Jingqu Chen, Gan Lin, Joseph J Richardson, Irene Yarovsky, Frank Caruso

2020-09-23

We report a facile strategy for engineering diverse particles based on the supramolecular assembly of natural polyphenols and a se..

Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials

2020-09-01

Polyphenol-Mediated Assembly for Particle Engineering.

Jiajing Zhou, Zhixing Lin, Yi Ju, Md Arifur Rahim, Joseph J Richardson, Frank Caruso

2020-07-21

Polyphenols are naturally occurring compounds that are ubiquitous in plants and display a spectrum of physical, chemical, and biol..

Engineering of Nebulized Metal-Phenolic Capsules for Controlled Pulmonary Deposition

Yi Ju, Christina Cortez-Jugo, Jingqu Chen, Ting-Yi Wang, Andrew J Mitchell, Evelyn Tsantikos, Nadja Bertleff-Zieschang, Yu-Wei Lin, Jiaying Song, Yizhe Cheng, Srinivas Mettu, Md Arifur Rahim, Shuaijun Pan, Gyeongwon Yun, Margaret L Hibbs, Leslie Y Yeo, Christoph E Hagemeyer, Frank Caruso

2020-03-18

Particle-based pulmonary delivery has great potential for delivering inhalable therapeutics for local or systemic applications. Th..

Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting.

Wenjie Zhang, Quinn A Besford, Andrew J Christofferson, Patrick Charchar, Joseph J Richardson, Aaron Elbourne, Kristian Kempe, Christoph E Hagemeyer, Matthew R Field, Chris F McConville, Irene Yarovsky, Frank Caruso

2020-03-10

The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key chall..

Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials

Yiyuan Han, Zhixing Lin, Jiajing Zhou, Gyeongwon Yun, Rui Guo, Joseph J Richardson, Frank Caruso

2020-03-01

Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins..

Expanding the Toolbox of Metal–Phenolic Networks via Enzyme‐Mediated Assembly

Qi‐Zhi Zhong, Joseph J Richardson, Shiyao Li, Wenjie Zhang, Yi Ju, Jianhua Li, Shuaijun Pan, Jingqu Chen, Frank Caruso

2020-01-20

<jats:title>Abstract</jats:title><jats:p>Functional coatings are of considerable interest because of their fundamental implication..

Ordered Mesoporous Metal-Phenolic Network Particles.

Zhixing Lin, Jiajing Zhou, Christina Cortez-Jugo, Yiyuan Han, Yutian Ma, Shuaijun Pan, Eric Hanssen, Joseph J Richardson, Frank Caruso

2020-01-08

Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in diverse fields inclu..

Self-Assembly of a Metal-Phenolic Sorbent for Broad-Spectrum Metal Sequestration

Md Arifur Rahim, Gan Lin, Pietro Pacchin Tomanin, Yi Ju, Anders Barlow, Mattias Bjornmalm, Frank Caruso

2020-01-08

Metal contamination of water bodies from industrial effluents presents a global threat to the aquatic ecosystem. To address this c..

The Biomolecular Corona in 2D and Reverse: Patterning Metal–Phenolic Networks on Proteins, Lipids, Nucleic Acids, Polysaccharides, and Fingerprints

G Yun, JJ Richardson, M Capelli, Y Hu, QA Besford, ACG Weiss, H Lee, IS Choi, BC Gibson, P Reineck, F Caruso

2020-01-03

The adsorption of biomolecules onto nanomaterials can alter the performance of the nanomaterials in vitro and in vivo. Recent stud..

Modular Assembly of Host-Guest Metal-Phenolic Networks Using Macrocyclic Building Blocks

Shuaijun Pan, Rui Guo, Nadja Bertleff-Zieschang, Shanshan Li, Quinn A Besford, Qi-Zhi Zhong, Gyeongwon Yun, Yunti Zhang, Francesca Cavalieri, Yi Ju, Eirini Goudeli, Joseph J Richardson, Frank Caruso

2020-01-02

The manipulation of interfacial properties has broad implications for the development of high‐performance coatings. Metal–phenolic..

Expanding the Toolbox of Metal-Phenolic Networks via Enzyme-Mediated Assembly

Qi-Zhi Zhong, Joseph J Richardson, Shiyao Li, Wenjie Zhang, Yi Ju, Jianhua Li, Shuaijun Pan, Jingqu Chen, Frank Caruso

2020-01-01

Functional coatings are of considerable interest because of their fundamental implications for interfacial assembly and promise fo..

Metal-Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles.

Jingqu Chen, Jianhua Li, Jiajing Zhou, Zhixing Lin, Francesca Cavalieri, Ewa Czuba-Wojnilowicz, Yingjie Hu, Agata Glab, Yi Ju, Joseph J Richardson, Frank Caruso

2019-10-22

The intracellular delivery of functional nanoparticles (NPs) and the release of therapeutic payloads at a target site are central ..

Oxidation-Mediated Kinetic Strategies for Engineering Metal-Phenolic Networks

Qi-Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-09-02

The tunable growth of metal–organic materials has implications for engineering particles and surfaces for diverse applications. Sp..

Oxidation‐Mediated Kinetic Strategies for Engineering Metal–Phenolic Networks

Qi‐Zhi Zhong, Shiyao Li, Jingqu Chen, Ke Xie, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-09-02

<jats:title>Abstract</jats:title><jats:p>The tunable growth of metal–organic materials has implications for engineering particles ..

Nebulization of Phenolic Capsules for Pulmonary Delivery

Christina Cortez-Jugo, Yi Ju, Leslie Yeo, Christoph Hagemeyer, Frank Caruso

2019-06-24

Oral presentation at 10th International Conference on Materials for Advanced Technologies

Selective Metal-Phenolic Assembly from Complex Multicomponent Mixtures

G Lin, MA Rahim, MG Leeming, C Cortez-Jugo, QA Besford, Y Ju, QZ Zhong, ST Johnston, J Zhou, F Caruso

2019-05-15

Selective self-assembly in multicomponent mixtures offers a method for isolating desired components from complex systems for the r..

Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films

BL Tardy, JJ Richardson, V Nithipipat, K Kempe, J Guo, KL Cho, MA Rahim, H Ejima, F Caruso

2019-03-11

Metal-phenolic network (MPN) coatings have generated increasing interest owing to their biologically inspired nature, facile fabri..

Tuning the Mechanical Behavior of Metal-Phenolic Networks through Building Block Composition

G Yun, JJ Richardson, M Biviano, F Caruso

2019-02-13

Metal-phenolic networks (MPNs) are an emerging class of functional metal-organic materials with a high degree of modularity in ter..

Phenolic Building Blocks for the Assembly of Functional Materials

MA Rahim, SL Kristufek, S Pan, JJ Richardson, F Caruso

2019-02-11

Phenolic materials have long been known for their use in inks, wood coatings, and leather tanning. However, there has recently bee..

Phenolische Bausteine für die Assemblierung von Funktionsmaterialien

Md Arifur Rahim, Samantha L Kristufek, Shuaijun Pan, Joseph J Richardson, Frank Caruso

2019-02-11

<jats:title>Abstract</jats:title><jats:p>Phenolische Materialien sind seit langem für ihre Verwendung in Farbtinten, in Holzbeschi..

Nebulization of Phenolic Capsules for Pulmonary Delivery

Christina Cortez-Jugo, Yi Ju, Leslie Yeo, Christoph Hagemeyer, Frank Caruso

2018-11-30

Oral presentation at ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Annual Research Workshop

Spray Assembly of Metal-Phenolic Networks: Formation, Growth, and Applications

QZ Zhong, S Pan, MA Rahim, G Yun, J Li, Y Ju, Z Lin, Y Han, Y Ma, JJ Richardson, F Caruso

2018-10-03

Hybrid conformal coatings, such as metal-phenolic networks (MPNs) that are constructed from the coordination-driven assembly of na..

Designing Particles for Biological Interactions

Frank Caruso

2018-07-31

Oral presentation at ACS Publications Symposium - Innovative Materials for a Sustainable World

Supramolecular Metal–Phenolic Gels for the Crystallization of Active Pharmaceutical Ingredients

MA Rahim, Y Hata, M Björnmalm, Y Ju, F Caruso

2018-06-27

The use of supramolecular gel media for the crystallization of active pharmaceutical ingredients (APIs) is of interest for control..

Self-Assembly of Nano- to Macroscopic Metal–Phenolic Materials

G Yun, Quinn Besford, S Johnston, JJ Richardson, Shuaijun Pan, M Biviano, F Caruso

2018-01-01

The self-assembly of molecular building blocks into well-defined macroscopic materials is desirable for developing emergent functi..

University of Melbourne Researchers

Frank Caruso